ABCC8
Gastrointestinal & Hepatic System · Phase I & Phase II Xenobiotic Detoxification
Why can ABCC8 be relevant to unusual blood-sugar problems?
ABCC8 makes part of a potassium channel that helps pancreatic beta cells regulate insulin release. Certain disease-causing changes disturb this control, so interpretation depends on the exact variant and the pattern of glucose abnormalities.
- Common Gene Name
- ATP binding cassette subfamily C member 8
- NCBI Gene ID
- 6833
- Chromosome
- 11
Clinical Evidence Status
Established disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (7 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| monogenic diabetes | ClinGen gene-disease validity | Definitive | Semidominant | View source 2022-07-24 |
| pulmonary arterial hypertension | ClinGen gene-disease validity | Moderate | Autosomal dominant | View source 2025-03-12 |
| hyperinsulinism | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2026-01-20 |
| hyperinsulinemic hypoglycemia, familial, 1 | ClinGen gene-disease validity | Definitive | Autosomal recessive | View source 2026-01-20 |
| Congenital hyperinsulinism | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2026-01 | |
| Permanent neonatal diabetes mellitus | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2026-01 | |
| Maturity-onset diabetes of the young | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2026-01 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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