ACADM

Metabolic System · Fatty Acid Beta-Oxidation (Mitochondrial & Peroxisomal)

Why can a fat-processing enzyme matter during fasting?

ACADM makes MCAD, a mitochondrial enzyme that breaks down medium-chain fatty acids. This pathway helps supply energy when the body relies on stored fat, which explains the importance of confirmed MCAD deficiency.

Common Gene Name
acyl-CoA dehydrogenase medium chain
NCBI Gene ID
34
Chromosome
1

Clinical Evidence Status

Actionability report availableEstablished disease relationship

These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.

Answer Sources

Explore supporting evidence (3 records)
Condition or drugEvidenceGrade / statusContextSource
medium chain acyl-CoA dehydrogenase deficiencyClinGen gene-disease validityDefinitiveAutosomal recessiveView source
2018-01-23
Medium-chain acyl coenzyme A dehydrogenase deficiencyClinGen clinical actionabilityScored report; not a validity gradeAdultView source
2023-10-16
Medium-chain acyl coenzyme A dehydrogenase deficiencyClinGen clinical actionabilityScored report; not a validity gradePediatricView source
2023-10-16

Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.

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