ADA
Metabolic System · Purine & Pyrimidine Metabolism
Why can an enzyme found throughout the body be especially important for immunity?
ADA makes adenosine deaminase, an enzyme particularly abundant in lymphocytes. These immune cells depend on appropriate handling of nucleoside metabolites to develop and function normally.
- Common Gene Name
- adenosine deaminase
- NCBI Gene ID
- 100
- Chromosome
- 20
Clinical Evidence Status
Established disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (2 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency | ClinGen gene-disease validity | Definitive | Autosomal recessive | View source 2020-11-19 |
| Adenosine deaminase deficiency | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2024-05 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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