ADAM17
Universal Cellular Machinery · Proteolysis & Protease Inhibition
How can cutting a surface protein change communication between cells?
ADAM17 makes a membrane-associated protease that processes selected proteins. Such processing can change the availability of signaling molecules and receptors used in cellular interactions.
- Common Gene Name
- ADAM metallopeptidase domain 17
- NCBI Gene ID
- 6868
- Chromosome
- 2
Clinical Evidence Status
Established disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (2 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| congenital heart disease | ClinGen gene-disease validity | Limited | Autosomal dominant | View source 2023-08-14 |
| inflammatory skin and bowel disease, neonatal, 1 | ClinGen gene-disease validity | Definitive | Autosomal recessive | View source 2026-08-18 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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