ANK2
Cardiovascular System · Cardiac Electrophysiology & Conduction
Can an ANK2 result explain an irregular heartbeat?
ANK2 makes ankyrin-B, a scaffold that organizes proteins at cell membranes. Its role in cell signaling makes it biologically relevant, but a particular rhythm disorder needs evidence for the exact variant and condition rather than the gene name alone.
- Common Gene Name
- ankyrin 2
- NCBI Gene ID
- 287
- Chromosome
- 4
Clinical Evidence Status
Established disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (6 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| catecholaminergic polymorphic ventricular tachycardia | ClinGen gene-disease validity | Disputed | Autosomal dominant | View source 2021-01-20 |
| long QT syndrome | ClinGen gene-disease validity | Disputed | Autosomal dominant | View source 2020-12-15 |
| Brugada syndrome | ClinGen gene-disease validity | Disputed | Autosomal dominant | View source 2017-11-21 |
| complex neurodevelopmental disorder | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2020-10-21 |
| Ankyrin-B syndrome | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2017-03 | |
| Autism spectrum disorder | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2017-03 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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