APC

Developmental System · Morphogenesis & Embryonic Axis Patterning

What does APC normally do to protect against uncontrolled growth?

APC helps restrain Wnt signaling, a pathway that controls cell growth and division. Some pathogenic variants weaken that restraint and can cause inherited cancer-predisposition syndromes, while many other variants do not.

Common Gene Name
APC regulator of Wnt signaling pathway
NCBI Gene ID
324
Chromosome
5

Clinical Evidence Status

Actionability report availableEstablished disease relationshipTumor or drug-label biomarker context

These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.

Answer Sources

Explore supporting evidence (8 records)
Condition or drugEvidenceGrade / statusContextSource
gastric adenocarcinoma and proximal polyposis of the stomachClinGen gene-disease validityDefinitiveAutosomal dominantView source
2022-06-20
classic or attenuated familial adenomatous polyposisClinGen gene-disease validityDefinitiveAutosomal dominantView source
2022-06-20
Familial adenomatous polyposisMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2025-08
Desmoid tumorMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2025-08
Primary macronodular adrenal hyperplasiaMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2025-08
Familial Adenomatous PolyposisClinGen clinical actionabilityScored report; not a validity gradeAdultView source
2022-02-09
Familial Adenomatous PolyposisClinGen clinical actionabilityScored report; not a validity gradePediatricView source
2023-06-28
Nirogacestat (1)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source

Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.

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