APOE
Metabolic System · Cholesterol & Lipoprotein Metabolism
Does an APOE result tell me for certain whether I will get Alzheimer's disease?
APOE makes a protein involved in transporting and redistributing fats, including cholesterol. Some alleles influence Alzheimer's susceptibility, but they do not determine with certainty whether an individual will develop the disease.
- Common Gene Name
- apolipoprotein E
- NCBI Gene ID
- 348
- Chromosome
- 19
Clinical Evidence Status
Tumor or drug-label biomarker context
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (8 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| Alzheimer disease | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2018-10 | |
| Age-related macular degeneration | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2018-10 | |
| Age-related hearing loss | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2018-10 | |
| Dementia with Lewy bodies | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2018-10 | |
| Aducanumab-avwa | FDA labeling biomarker | Label mentions biomarker; actionability not inferred | Neurology | View source |
| Lecanemab-irmb | FDA labeling biomarker | Label mentions biomarker; actionability not inferred | Neurology | View source |
| Donanemab-azbt | FDA labeling biomarker | Label mentions biomarker; actionability not inferred | Neurology | View source |
| Anti-amyloid treatment ARIA risk | FDA drug safety context | Treatment-specific risk counseling | Diagnosed Alzheimer disease; relevant therapy and genotype | View source |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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