APP
Nervous System · Synaptic Plasticity & Neurotransmission
Does having APP mean amyloid is building up in my brain?
APP encodes amyloid precursor protein, which is processed into smaller fragments. Everyone has this gene, and a DNA finding does not directly measure amyloid accumulation.
- Common Gene Name
- amyloid beta precursor protein
- NCBI Gene ID
- 351
- Chromosome
- 21
Clinical Evidence Status
Established disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (3 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| cerebral amyloid angiopathy, APP-related | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2025-10-22 |
| Alzheimer disease | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2022-04 | |
| Hereditary cerebral amyloid angiopathy | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2022-04 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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