ATM
Universal Cellular Machinery · DNA Damage Repair & Genomic Integrity
How do cells notice broken DNA and coordinate a response?
ATM encodes a kinase involved in recognizing DNA damage and controlling downstream repair and cell-cycle signals. The effects of a genetic finding depend on its type and inheritance, rather than on the gene's repair role alone.
- Common Gene Name
- ATM serine/threonine kinase
- NCBI Gene ID
- 472
- Chromosome
- 11
Clinical Evidence Status
Actionability report availableEstablished disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (6 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| ataxia telangiectasia | ClinGen gene-disease validity | Definitive | Autosomal recessive | View source 2021-07-27 |
| ATM-related cancer predisposition | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2024-11-22 |
| Bladder cancer | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2022-09 | |
| Breast cancer | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2022-09 | |
| Melanoma | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2022-09 | |
| Breast Cancer | ClinGen clinical actionability | Scored report; not a validity grade | Adult | View source 2022-08-01 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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