ATP2A2
Musculoskeletal System · Excitation-Contraction Coupling
How do cells put calcium signals back into storage?
ATP2A2 encodes SERCA2, a pump that moves calcium into internal cellular compartments. This helps restore calcium balance after signals, including those used in muscle activity.
- Common Gene Name
- ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
- NCBI Gene ID
- 488
- Chromosome
- 12
Clinical Evidence Status
Disease evidence limited or conflicting
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (2 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| epilepsy | ClinGen gene-disease validity | Refuted | Autosomal dominant | View source 2026-06-16 |
| Darier disease | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2024-01 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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