BAP1
Universal Cellular Machinery · Ubiquitin-Proteasome Degradation
How can removing a ubiquitin tag change a protein's fate?
BAP1 encodes an enzyme that removes ubiquitin from selected proteins. This can alter their activity, interactions, or degradation and contributes to cellular growth-control pathways.
- Common Gene Name
- BRCA1 associated deubiquitinase 1
- NCBI Gene ID
- 8314
- Chromosome
- 3
Clinical Evidence Status
Actionability report availableEstablished disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (5 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| BAP1-related tumor predisposition syndrome | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2019-03-21 |
| Cholangiocarcinoma | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2017-01 | |
| BAP1 tumor predisposition syndrome | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2017-01 | |
| Melanoma | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2017-01 | |
| Tumor Predisposition Syndrome | ClinGen clinical actionability | Scored report; not a validity grade | Adult | View source 2022-02-09 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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