BCL2
Universal Cellular Machinery · Apoptosis & Programmed Cell Death
Why can keeping a cell alive be either helpful or harmful?
BCL2 encodes a protein that inhibits programmed cell death. Preserving needed cells is normal, but excessive survival signaling can allow abnormal cells to persist.
- Common Gene Name
- BCL2 apoptosis regulator
- NCBI Gene ID
- 596
- Chromosome
- 18
Clinical Evidence Status
Tumor or drug-label biomarker context
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (2 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| Polatuzumab Vedotin-piiq (1) | FDA labeling biomarker | Label mentions biomarker; actionability not inferred | Oncology | View source |
| Brentuximab Vedotin (4) | FDA labeling biomarker | Label mentions biomarker; actionability not inferred | Oncology | View source |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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