BMPR2
Respiratory System · Pulmonary Gas Exchange & Ventilatory Control
Why is a bone-morphogenetic receptor relevant to blood vessels?
BMPR2 makes a receptor in a signaling family whose roles extend beyond bone and cartilage. It helps regulate growth and specialization in multiple cell types, including vascular tissues.
- Common Gene Name
- bone morphogenetic protein receptor type 2
- NCBI Gene ID
- 659
- Chromosome
- 2
Clinical Evidence Status
Actionability report availableEstablished disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (4 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| congenital heart disease | ClinGen gene-disease validity | Limited | Autosomal dominant | View source 2023-09-18 |
| pulmonary arterial hypertension | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2020-12-07 |
| Pulmonary veno-occlusive disease | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2016-01 | |
| Primary pulmonary hypertension 1 | ClinGen clinical actionability | Scored report; not a validity grade | Adult | View source 2022-03-14 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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