BRCA1
Universal Cellular Machinery · DNA Damage Repair & Genomic Integrity
Does a BRCA1 variant mean I already have cancer?
BRCA1 makes a protein that helps repair damaged DNA and restrain abnormal growth. A confirmed pathogenic variant can increase susceptibility to certain cancers, but it does not show that cancer is present.
- Common Gene Name
- BRCA1 DNA repair associated
- NCBI Gene ID
- 672
- Chromosome
- 17
Clinical Evidence Status
Actionability report availableEstablished disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (8 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| BRCA1-related cancer predisposition | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2024-08-29 |
| Fanconi anemia, complementation group S | ClinGen gene-disease validity | Definitive | Autosomal recessive | View source 2020-05-14 |
| Breast cancer | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-09 | |
| Fanconi anemia | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-09 | |
| Prostate cancer | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-09 | |
| Ovarian cancer | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-09 | |
| Cholangiocarcinoma | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-09 | |
| Hereditary Breast and Ovarian Cancer | ClinGen clinical actionability | Scored report; not a validity grade | Adult | View source 2025-08-14 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
← Back to Universal Cellular Machinery