BRCA2
Universal Cellular Machinery · DNA Damage Repair & Genomic Integrity
Can a negative consumer BRCA2 screen rule out inherited cancer risk?
BRCA2 encodes a DNA-repair protein, and some pathogenic variants carry inherited cancer implications. A limited consumer screen may not assess all relevant variants or genes, so its scope matters when interpreting a negative result.
- Common Gene Name
- BRCA2 DNA repair associated
- NCBI Gene ID
- 675
- Chromosome
- 13
Clinical Evidence Status
Actionability report availableEstablished disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (10 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| Fanconi anemia complementation group D1 | ClinGen gene-disease validity | Definitive | Autosomal recessive | View source 2019-04-19 |
| BRCA2-related cancer predisposition | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2024-08-29 |
| Breast cancer | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-09 | |
| Fanconi anemia | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-09 | |
| Prostate cancer | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-09 | |
| Ovarian cancer | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-09 | |
| Cholangiocarcinoma | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-09 | |
| Fanconi Anemia | ClinGen clinical actionability | Scored report; not a validity grade | Adult | View source 2025-09-23 |
| Hereditary Breast and Ovarian Cancer | ClinGen clinical actionability | Scored report; not a validity grade | Adult | View source 2025-08-14 |
| Fanconi Anemia | ClinGen clinical actionability | Scored report; not a validity grade | Pediatric | View source 2025-09-23 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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