C3
Immune System · Complement Activation & Opsonization
Why is C3 often called a central complement protein?
C3 encodes a protein required for key activation steps in the complement system. Its position in this network connects it to microbial defense, inflammation, and clearance of damaged material.
- Common Gene Name
- complement C3
- NCBI Gene ID
- 718
- Chromosome
- 19
Clinical Evidence Status
Established disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (5 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| C3 glomerulonephritis | ClinGen gene-disease validity | Moderate | Autosomal dominant | View source 2024-03-29 |
| atypical hemolytic-uremic syndrome with C3 anomaly | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2023-09-29 |
| Atypical hemolytic-uremic syndrome | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-12 | |
| C3 glomerulopathy | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-12 | |
| Age-related macular degeneration | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-12 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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