CBS
Metabolic System · Vitamin, Cofactor & One-Carbon Metabolism
Does a CBS variant automatically call for vitamin B6?
CBS makes a vitamin-B6-dependent enzyme that helps convert homocysteine into another sulfur-containing compound. A common variant does not establish enzyme deficiency or a need for a particular supplement regimen.
- Common Gene Name
- cystathionine beta-synthase
- NCBI Gene ID
- 875
- Chromosome
- 21
Clinical Evidence Status
Actionability report availableEstablished disease relationshipTumor or drug-label biomarker context
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (5 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| classic homocystinuria | ClinGen gene-disease validity | Definitive | Autosomal recessive | View source 2019-04-12 |
| Homocystinuria | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2011-07 | |
| Cystathionine Beta-Synthase Deficiency | ClinGen clinical actionability | Scored report; not a validity grade | Adult | View source 2023-10-06 |
| Cystathionine Beta-Synthase Deficiency | ClinGen clinical actionability | Scored report; not a validity grade | Pediatric | View source 2023-10-06 |
| Betaine | FDA labeling biomarker | Label mentions biomarker; actionability not inferred | Inborn Errors of Metabolism | View source |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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