CDH1

Universal Cellular Machinery · Cell Adhesion & Extracellular Matrix Architecture

What holds neighboring epithelial cells together?

CDH1 makes E-cadherin, a membrane protein that helps cells adhere and form organized tissues. Certain pathogenic variants have cancer-predisposition implications, but the structural role is also essential in normal cells.

Common Gene Name
cadherin 1
NCBI Gene ID
999
Chromosome
16

Clinical Evidence Status

Actionability report availableEstablished disease relationship

These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.

Answer Sources

Explore supporting evidence (9 records)
Condition or drugEvidenceGrade / statusContextSource
familial ovarian cancerClinGen gene-disease validityNo Known Disease RelationshipAutosomal dominantView source
2017-08-03
CDH1-related diffuse gastric and lobular breast cancer syndromeClinGen gene-disease validityDefinitiveAutosomal dominantView source
2024-03-22
Breast cancerMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2017-07
Hereditary diffuse gastric cancerMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2017-07
Prostate cancerMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2017-07
Ovarian cancerMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2017-07
Blepharocheilodontic syndromeMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2017-07
Hereditary Diffuse Gastric CancerClinGen clinical actionabilityScored report; not a validity gradeAdultView source
2023-12-20
Hereditary Diffuse Gastric CancerClinGen clinical actionabilityScored report; not a validity gradePediatricView source
2023-12-20

Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.

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