CDKN1B
Universal Cellular Machinery · Cell Cycle Control & Mitotic Division
What is the role of p27 in controlling cell division?
CDKN1B encodes p27, a protein that restrains cell-cycle progression. It helps cells coordinate when to divide instead of allowing growth signals to proceed unchecked.
- Common Gene Name
- cyclin dependent kinase inhibitor 1B
- NCBI Gene ID
- 1027
- Chromosome
- 12
Clinical Evidence Status
Actionability report availableEstablished disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (5 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| multiple endocrine neoplasia type 4 | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2018-12-21 |
| hereditary nonpolyposis colon cancer | ClinGen gene-disease validity | Limited | Autosomal recessive | View source 2017-06-08 |
| Multiple endocrine neoplasia | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2013-08 | |
| Multiple endocrine neoplasia type 4 | ClinGen clinical actionability | Scored report; not a validity grade | Adult | View source 2024-02-13 |
| Multiple endocrine neoplasia type 4 | ClinGen clinical actionability | Scored report; not a validity grade | Pediatric | View source 2024-02-13 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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