CDKN2A
Universal Cellular Machinery · Cell Cycle Control & Mitotic Division
How can CDKN2A supply more than one growth-control protein?
CDKN2A produces distinct proteins, including p16 and p14, through different transcript arrangements. Both participate in tumor-suppressor pathways that limit inappropriate cell division.
- Common Gene Name
- cyclin dependent kinase inhibitor 2A
- NCBI Gene ID
- 1029
- Chromosome
- 9
Clinical Evidence Status
Actionability report availableEstablished disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (7 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| melanoma-pancreatic cancer syndrome | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2019-08-14 |
| Bladder cancer | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2018-07 | |
| Head and neck squamous cell carcinoma | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2018-07 | |
| Lung cancer | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2018-07 | |
| Melanoma | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2018-07 | |
| Pancreatic cancer/melanoma syndrome | ClinGen clinical actionability | Scored report; not a validity grade | Adult | View source 2022-10-04 |
| Pancreatic cancer/melanoma syndrome | ClinGen clinical actionability | Scored report; not a validity grade | Pediatric | View source 2022-10-04 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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