CFB
Immune System · Complement Activation & Opsonization
How does CFB help amplify a complement response?
CFB makes factor B, which contributes to an enzyme complex in the alternative complement pathway. That complex helps activate more C3, strengthening an ongoing immune response.
- Common Gene Name
- complement factor B
- NCBI Gene ID
- 629
- Chromosome
- 6
Clinical Evidence Status
Disease evidence limited or conflicting
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (2 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| atypical hemolytic-uremic syndrome with B factor anomaly | ClinGen gene-disease validity | Moderate | Autosomal dominant | View source 2023-07-02 |
| C3 glomerulonephritis | ClinGen gene-disease validity | Limited | Autosomal dominant | View source 2024-11-27 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
← Back to Immune System