CFH
Immune System · Complement Activation & Opsonization
Why does an immune-defense system need CFH as a regulator?
CFH makes factor H, which helps keep complement activity directed at appropriate targets. Regulation matters because an unchecked protective response can also damage the body's own cells.
- Common Gene Name
- complement factor H
- NCBI Gene ID
- 3075
- Chromosome
- 1
Clinical Evidence Status
Established disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (4 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| C3 glomerulonephritis | ClinGen gene-disease validity | Definitive | Autosomal recessive | View source 2024-02-21 |
| atypical hemolytic-uremic syndrome | ClinGen gene-disease validity | Definitive | Semidominant | View source 2023-07-02 |
| C3 glomerulopathy | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-12 | |
| Age-related macular degeneration | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-12 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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