CFI

Immune System · Complement Activation & Opsonization

How does CFI help prevent complement from staying active too long?

CFI makes factor I, a protein that helps limit complement activity by processing complement components. This control supports immune defense while reducing damage to healthy tissue.

Common Gene Name
complement factor I
NCBI Gene ID
3426
Chromosome
4

Clinical Evidence Status

Established disease relationship

These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.

Answer Sources

Explore supporting evidence (5 records)
Condition or drugEvidenceGrade / statusContextSource
atypical hemolytic-uremic syndromeClinGen gene-disease validityDefinitiveAutosomal dominantView source
2023-06-01
C3 glomerulonephritisClinGen gene-disease validityModerateAutosomal dominantView source
2024-06-28
Complement factor I deficiencyMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2010-09
C3 glomerulopathyMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2010-09
Age-related macular degenerationMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2010-09

Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.

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