CHEK2
Universal Cellular Machinery · DNA Damage Repair & Genomic Integrity
What does CHEK2 do when DNA copying encounters a problem?
CHEK2 makes a checkpoint kinase that helps halt cell-cycle progression after damage or replication stress. This pause supports protective responses before a cell continues dividing.
- Common Gene Name
- checkpoint kinase 2
- NCBI Gene ID
- 11200
- Chromosome
- 22
Clinical Evidence Status
Actionability report availableEstablished disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (4 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| CHEK2-related cancer predisposition | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2024-11-04 |
| familial ovarian cancer | ClinGen gene-disease validity | Refuted | Autosomal dominant | View source 2024-11-04 |
| hereditary nonpolyposis colon cancer | ClinGen gene-disease validity | Limited | Autosomal dominant | View source 2017-03-13 |
| Breast Cancer | ClinGen clinical actionability | Scored report; not a validity grade | Adult | View source 2022-08-01 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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