CTLA4
Immune System · T-Cell Signaling, Differentiation & Checkpoint Tolerance
Why does the immune system need the CTLA4 brake?
CTLA4 makes a receptor that sends inhibitory signals to T cells. This restraint helps regulate immune activation, showing why reducing a response can be as necessary as starting one.
- Common Gene Name
- cytotoxic T-lymphocyte associated protein 4
- NCBI Gene ID
- 1493
- Chromosome
- 2
Clinical Evidence Status
Established disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (1 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2020-12-15 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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