CTNNB1
Developmental System · Morphogenesis & Embryonic Axis Patterning
Why is CTNNB1 relevant to both tissue development and cancer?
CTNNB1 makes beta-catenin, which helps cells adhere to each other and communicate growth signals. Altered signaling can have different consequences in developing tissues and in tumor cells.
- Common Gene Name
- catenin beta 1
- NCBI Gene ID
- 1499
- Chromosome
- 3
Clinical Evidence Status
Established disease relationshipTumor or drug-label biomarker context
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (8 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| CTNNB1-related neurodevelopmental disorder and/or vitreoretinopathy | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2024-02-08 |
| Familial exudative vitreoretinopathy | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2025-08 | |
| Pilomatricoma | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2025-08 | |
| Desmoid tumor | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2025-08 | |
| Ovarian cancer | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2025-08 | |
| Aldosterone-producing adenoma | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2025-08 | |
| Wilms tumor | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2025-08 | |
| Nirogacestat (2) | FDA labeling biomarker | Label mentions biomarker; actionability not inferred | Oncology | View source |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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