CXCR4
Immune System · Leukocyte Extravasation & Chemotaxis
What does CXCR4 tell a cell about where to go?
CXCR4 makes a receptor that responds to a guidance signal called SDF-1. The resulting pathways influence cell movement and behavior, including those of white blood cells.
- Common Gene Name
- C-X-C motif chemokine receptor 4
- NCBI Gene ID
- 7852
- Chromosome
- 2
Clinical Evidence Status
Established disease relationshipTumor or drug-label biomarker context
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (3 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| WHIM syndrome | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2023-01-17 |
| Waldenström macroglobulinemia | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-03 | |
| Mavorixafor | FDA labeling biomarker | Label mentions biomarker; actionability not inferred | Hematology | View source |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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