CYP21A2
Endocrine System · Steroidogenesis & Nuclear Hormone Signaling
Why is CYP21A2 important for the adrenal glands?
CYP21A2 makes 21-hydroxylase, an enzyme needed to produce cortisol and aldosterone. These hormones help regulate stress responses and salt balance, so suspected enzyme deficiency requires a specific genetic and biochemical assessment.
- Common Gene Name
- cytochrome P450 family 21 subfamily A member 2
- NCBI Gene ID
- 1589
- Chromosome
- 6
Clinical Evidence Status
Actionability report available
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (2 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| 21-hydroxylase deficiency | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2010-01 | |
| Hyperandrogenism, nonclassic type, due to 21-hydroxylase deficiency | ClinGen clinical actionability | Scored report; not a validity grade | Adult | View source 2022-02-09 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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