CYP27A1
Gastrointestinal & Hepatic System · Bile Acid Synthesis & Canalicular Excretion
What connects CYP27A1 with digesting dietary fat?
CYP27A1 produces an enzyme involved in converting cholesterol into bile acids. Bile acids help the digestive system handle fats, connecting a cellular cholesterol pathway to digestion.
- Common Gene Name
- cytochrome P450 family 27 subfamily A member 1
- NCBI Gene ID
- 1593
- Chromosome
- 2
Clinical Evidence Status
Actionability report availableEstablished disease relationshipTumor or drug-label biomarker context
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (4 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| cerebrotendinous xanthomatosis | ClinGen gene-disease validity | Definitive | Autosomal recessive | View source 2024-09-23 |
| Cerebrotendinous xanthomatosis | ClinGen clinical actionability | Scored report; not a validity grade | Adult | View source 2025-12-18 |
| Cerebrotendinous xanthomatosis | ClinGen clinical actionability | Scored report; not a validity grade | Pediatric | View source 2025-12-18 |
| Cholic Acid | FDA labeling biomarker | Label mentions biomarker; actionability not inferred | Inborn Errors of Metabolism | View source |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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