CYP2D6

Genomic Regulatory Elements · Pseudogenes & Genomic Relics

Why might a CYP2D6 result need more than a single SNP?

CYP2D6 makes an enzyme that processes several classes of medicines. Interpreting its activity can require the combination of variants and gene-copy information, so an isolated consumer marker may not establish a metabolizer category.

Common Gene Name: cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)
NCBI Gene ID: 1565
Chromosome: 22

Clinical Evidence Status

Drug-response evidence availableTumor or drug-label biomarker context

These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.

Answer Sources

Explore supporting evidence (129 records)

Condition or drug	Evidence	Grade / status	Context	Source
Amphetamine	FDA pharmacogenetics	Management recommendation	Drug-specific subgroup	View source
Aripiprazole	FDA pharmacogenetics	Management recommendation	Drug-specific subgroup	View source
Aripiprazole Lauroxil	FDA pharmacogenetics	Management recommendation	Drug-specific subgroup	View source
Atomoxetine	FDA pharmacogenetics	Management recommendation	Drug-specific subgroup	View source
Brexpiprazole	FDA pharmacogenetics	Management recommendation	Drug-specific subgroup	View source
Clozapine	FDA pharmacogenetics	Management recommendation	Drug-specific subgroup	View source
Codeine	FDA pharmacogenetics	Management recommendation	Drug-specific subgroup	View source
Deutetrabenazine	FDA pharmacogenetics	Management recommendation	Drug-specific subgroup	View source
Eliglustat	FDA pharmacogenetics	Management recommendation	Drug-specific subgroup	View source
Gefitinib	FDA pharmacogenetics	Management recommendation	Drug-specific subgroup	View source
Iloperidone	FDA pharmacogenetics	Management recommendation	Drug-specific subgroup	View source
Lofexidine	FDA pharmacogenetics	Management recommendation	Drug-specific subgroup	View source
Meclizine	FDA pharmacogenetics	Management recommendation	Drug-specific subgroup	View source
Metoclopramide	FDA pharmacogenetics	Management recommendation	Drug-specific subgroup	View source
Oliceridine	FDA pharmacogenetics	Management recommendation	Drug-specific subgroup	View source
Pimozide	FDA pharmacogenetics	Management recommendation	Drug-specific subgroup	View source
Pitolisant	FDA pharmacogenetics	Management recommendation	Drug-specific subgroup	View source
Propafenone	FDA pharmacogenetics	Management recommendation	Drug-specific subgroup	View source
Tetrabenazine	FDA pharmacogenetics	Management recommendation	Drug-specific subgroup	View source
Thioridazine	FDA pharmacogenetics	Management recommendation	Drug-specific subgroup	View source
Tramadol	FDA pharmacogenetics	Management recommendation	Drug-specific subgroup	View source
Valbenazine	FDA pharmacogenetics	Management recommendation	Drug-specific subgroup	View source
Venlafaxine	FDA pharmacogenetics	Management recommendation	Drug-specific subgroup	View source
Vortioxetine	FDA pharmacogenetics	Management recommendation	Drug-specific subgroup	View source
Carvedilol	FDA pharmacogenetics	Potential safety or response effect	Drug-specific subgroup	View source
Cevimeline	FDA pharmacogenetics	Potential safety or response effect	Drug-specific subgroup	View source
Codeine	FDA pharmacogenetics	Potential safety or response effect	Drug-specific subgroup	View source
Perphenazine	FDA pharmacogenetics	Potential safety or response effect	Drug-specific subgroup	View source
Tolterodine	FDA pharmacogenetics	Potential safety or response effect	Drug-specific subgroup	View source
Tramadol	FDA pharmacogenetics	Potential safety or response effect	Drug-specific subgroup	View source
Amitriptyline	FDA pharmacogenetics	Pharmacokinetics only	Drug-specific subgroup	View source
Amoxapine	FDA pharmacogenetics	Pharmacokinetics only	Drug-specific subgroup	View source
Clomipramine	FDA pharmacogenetics	Pharmacokinetics only	Drug-specific subgroup	View source
Darifenacin	FDA pharmacogenetics	Pharmacokinetics only	Drug-specific subgroup	View source
Desipramine	FDA pharmacogenetics	Pharmacokinetics only	Drug-specific subgroup	View source
Donepezil	FDA pharmacogenetics	Pharmacokinetics only	Drug-specific subgroup	View source
Doxepin	FDA pharmacogenetics	Pharmacokinetics only	Drug-specific subgroup	View source
Fesoterodine	FDA pharmacogenetics	Pharmacokinetics only	Drug-specific subgroup	View source
Fluvoxamine	FDA pharmacogenetics	Pharmacokinetics only	Drug-specific subgroup	View source
Galantamine	FDA pharmacogenetics	Pharmacokinetics only	Drug-specific subgroup	View source
Imipramine	FDA pharmacogenetics	Pharmacokinetics only	Drug-specific subgroup	View source
Metoprolol	FDA pharmacogenetics	Pharmacokinetics only	Drug-specific subgroup	View source
Mirabegron	FDA pharmacogenetics	Pharmacokinetics only	Drug-specific subgroup	View source
Nebivolol	FDA pharmacogenetics	Pharmacokinetics only	Drug-specific subgroup	View source
Nortriptyline	FDA pharmacogenetics	Pharmacokinetics only	Drug-specific subgroup	View source
Paroxetine	FDA pharmacogenetics	Pharmacokinetics only	Drug-specific subgroup	View source
Propranolol	FDA pharmacogenetics	Pharmacokinetics only	Drug-specific subgroup	View source
Protriptyline	FDA pharmacogenetics	Pharmacokinetics only	Drug-specific subgroup	View source
Risperidone	FDA pharmacogenetics	Pharmacokinetics only	Drug-specific subgroup	View source
Tamoxifen	FDA pharmacogenetics	Pharmacokinetics only	Drug-specific subgroup	View source
Tamsulosin	FDA pharmacogenetics	Pharmacokinetics only	Drug-specific subgroup	View source
Trimipramine	FDA pharmacogenetics	Pharmacokinetics only	Drug-specific subgroup	View source
Viloxazine	FDA pharmacogenetics	Pharmacokinetics only	Drug-specific subgroup	View source
Amitriptyline	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Amoxapine	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Amphetamine	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Arformoterol (2)	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Pulmonary	View source
Aripiprazole	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Aripiprazole Lauroxil	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Atomoxetine	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Brexpiprazole	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Bupropion	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Bupropion and Dextromethorphan	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Cariprazine	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Carvedilol	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Cardiology	View source
Cevimeline	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Dental	View source
Citalopram (2)	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Clomipramine	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Clozapine	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Codeine	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Anesthesiology	View source
Darifenacin	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Urology	View source
Desipramine	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Desvenlafaxine	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Deutetrabenazine	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Neurology	View source
Dextromethorphan and Quinidine	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Neurology	View source
Donepezil	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Neurology	View source
Doxepin (1)	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Duloxetine	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Eliglustat	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Inborn Errors of Metabolism	View source
Escitalopram (1)	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Fesoterodine	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Urology	View source
Flibanserin (3)	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Gynecology	View source
Fluoxetine	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Fluvoxamine	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Formoterol (1)	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Pulmonary	View source
Galantamine	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Neurology	View source
Gefitinib (2)	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Oncology	View source
Iloperidone	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Imipramine	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Lofexidine	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Anesthesiology	View source
Meclizine	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Neurology	View source
Metoclopramide (3)	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Gastroenterology	View source
Metoprolol	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Cardiology	View source
Mirabegron	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Urology	View source
Modafinil	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Nebivolol	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Cardiology	View source
Nefazodone	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Nortriptyline	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Oliceridine	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Anesthesiology	View source
Ondansetron	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Gastroenterology	View source
Paliperidone	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Palonosetron	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Gastroenterology	View source
Paroxetine	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Perphenazine	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Pimozide	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Pitolisant	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Propafenone	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Cardiology	View source
Propranolol	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Cardiology	View source
Protriptyline	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Quinidine	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Cardiology	View source
Quinine Sulfate (2)	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Infectious Diseases	View source
Risperidone	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Rucaparib (2)	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Oncology	View source
Tamoxifen (4)	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Oncology	View source
Tamsulosin	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Urology	View source
Tetrabenazine	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Neurology	View source
Thioridazine	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Tolterodine	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Urology	View source
Tramadol	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Anesthesiology	View source
Trimipramine	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Umeclidinium	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Pulmonary	View source
Upadacitinib	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Rheumatology	View source
Valbenazine	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Neurology	View source
Venlafaxine	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Viloxazine (1)	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Vortioxetine	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Primaquine (3)	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Infectious Diseases	View source
Trospium and Xanomeline	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source
Milsaperidone	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Psychiatry	View source

Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.

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