DNM1L
Universal Cellular Machinery · Cytoskeletal Organization & Motor Transport
Why do mitochondria need a gene that helps them divide?
DNM1L makes a protein that participates in the division of mitochondria and peroxisomes. Controlled division helps cells organize these compartments and adjust their distribution.
- Common Gene Name
- dynamin 1L
- NCBI Gene ID
- 10059
- Chromosome
- 12
Clinical Evidence Status
Established disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (3 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| Leigh syndrome | ClinGen gene-disease validity | Limited | Autosomal recessive | View source 2021-06-30 |
| encephalopathy due to mitochondrial and peroxisomal fission defect | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2022-04-15 |
| Leigh syndrome | ClinGen gene-disease validity | Limited | Autosomal dominant | View source 2021-06-30 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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