DNMT1
Universal Cellular Machinery · Chromatin Remodeling & Epigenetic Regulation
What does DNA methylation do, and how is DNMT1 involved?
DNMT1 encodes an enzyme that adds methyl marks to DNA. These marks help regulate gene activity and cellular identity without changing the underlying DNA sequence.
- Common Gene Name
- DNA methyltransferase 1
- NCBI Gene ID
- 1786
- Chromosome
- 19
Clinical Evidence Status
Established disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (3 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| autosomal dominant cerebellar ataxia, deafness and narcolepsy | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2017-02-10 |
| Charcot-Marie-Tooth disease | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2017-07 | |
| Hereditary sensory and autonomic neuropathy type IE | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2017-07 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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