EGFR

Universal Cellular Machinery · Phosphorylation & Kinase Signaling Cascades

How does an epidermal growth signal reach the inside of a cell?

EGFR makes a receptor that binds growth-related signals outside the cell. Activation relays messages that influence cellular behavior, while drug relevance depends on a particular tumor's findings.

Common Gene Name
epidermal growth factor receptor
NCBI Gene ID
1956
Chromosome
7

Clinical Evidence Status

Established disease relationshipTumor or drug-label biomarker context

These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.

Answer Sources

Explore supporting evidence (27 records)
Condition or drugEvidenceGrade / statusContextSource
non-small cell lung carcinomaClinGen gene-disease validityDefinitiveAutosomal dominantView source
2020-07-30
Lung cancerMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2017-12
CholangiocarcinomaMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2017-12
AfatinibFDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Amivantamab-vmjwFDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Atezolizumab (3)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Cemiplimab-rwlc (3)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Cetuximab (1)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
DacomitinibFDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Durvalumab (2)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
ErlotinibFDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Gefitinib (1)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Ipilimumab (5)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
MobocertinibFDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Nivolumab (4)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
OsimertinibFDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Panitumumab (1)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Pembrolizumab (4)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Pemetrexed (2)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Ramucirumab (1)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Tepotinib (2)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Tremelimumab-actl (2)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Datopotamab Deruxtecan-dlnk (1)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Lazertinib (1)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Sevabertinib (2)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
SunvozertinibFDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Telisotuzumab Vedotin-tllv (1)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source

Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.

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