EIF2AK4
Respiratory System · Pulmonary Gas Exchange & Ventilatory Control
How do cells slow protein production when resources are limited?
EIF2AK4 makes a stress-response kinase that modifies a regulator of protein synthesis. This helps cells adjust production when amino acids or other conditions are unfavorable.
- Common Gene Name
- eukaryotic translation initiation factor 2 alpha kinase 4
- NCBI Gene ID
- 440275
- Chromosome
- 15
Clinical Evidence Status
Established disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (3 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| pulmonary veno-occlusive disease and/or pulmonary capillary haemangiomatosis | ClinGen gene-disease validity | Definitive | Autosomal recessive | View source 2022-12-02 |
| Pulmonary arterial hypertension | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-03 | |
| Pulmonary veno-occlusive disease | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-03 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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