EP300
Universal Cellular Machinery · Chromatin Remodeling & Epigenetic Regulation
How does p300 help a cell turn genes on?
EP300 encodes p300, a protein that cooperates with gene-regulating machinery. It helps coordinate the transcription programs needed for growth, specialization, and development.
- Common Gene Name
- EP300 lysine acetyltransferase
- NCBI Gene ID
- 2033
- Chromosome
- 22
Clinical Evidence Status
Established disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (4 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| Rubinstein-Taybi syndrome due to EP300 haploinsufficiency | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2022-05-20 |
| Bladder cancer | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2020-01 | |
| Rubinstein-Taybi syndrome | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2020-01 | |
| Prostate cancer | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2020-01 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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