ERBB2

Universal Cellular Machinery · Phosphorylation & Kinase Signaling Cascades

Is an ERBB2 variant the same as a HER2-positive tumor result?

ERBB2 encodes HER2, a receptor that partners with related growth-factor receptors. Tumor testing for HER2 expression or amplification measures specific cancer features and is not interchangeable with an inherited variant report.

Common Gene Name
erb-b2 receptor tyrosine kinase 2
NCBI Gene ID
2064
Chromosome
17

Clinical Evidence Status

Tumor or drug-label biomarker context

These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.

Answer Sources

Explore supporting evidence (34 records)
Condition or drugEvidenceGrade / statusContextSource
Abemaciclib (2)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Ado-Trastuzumab EmtansineFDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Alpelisib (1)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Capecitabine (2)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Capivasertib (2)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Elacestrant (2)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Eribulin (1)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Everolimus (1)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Fam-Trastuzumab Deruxtecan-nxki (1)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Fulvestrant (1)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Ixabepilone (1)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Lapatinib (1)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Margetuximab-cmkb (1)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Neratinib (1)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Nivolumab (6)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Olaparib (2)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Palbociclib (2)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Pembrolizumab (7)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Pertuzumab (1)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Ribociclib (2)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Sacituzumab Govitecan-hziy (4)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Talazoparib (2)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Tipiracil and Trifluridine (1)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Trastuzumab (1)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Tucatinib (1)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Datopotamab Deruxtecan-dlnk (3)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Imlunestrant (2)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Inavolisib (1)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Sevabertinib (1)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Tislelizumab-jsgr (2)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Zanidatamab-hriiFDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Zolbetuximab-clzb (2)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
ZongertinibFDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Vepdegestrant (1)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source

Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.

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