F2
Hematologic System · Coagulation, Fibrin Formation & Fibrinolysis
Does an F2 finding mean I am certain to get a blood clot?
F2 makes prothrombin, an essential protein in normal blood clotting. The significance of a finding depends on the specific variant and clinical history, so the gene name alone cannot predict a clot.
- Common Gene Name
- coagulation factor II, thrombin
- NCBI Gene ID
- 2147
- Chromosome
- 11
Clinical Evidence Status
Established disease relationshipTumor or drug-label biomarker context
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (7 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| thrombophilia due to thrombin defect | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2020-06-24 |
| congenital prothrombin deficiency | ClinGen gene-disease validity | Definitive | Autosomal recessive | View source 2020-06-24 |
| Prothrombin thrombophilia | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2025-01 | |
| Prothrombin deficiency | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2025-01 | |
| Avatrombopag (1) | FDA labeling biomarker | Label mentions biomarker; actionability not inferred | Hematology | View source |
| Lusutrombopag (1) | FDA labeling biomarker | Label mentions biomarker; actionability not inferred | Hematology | View source |
| Tamoxifen (3) | FDA labeling biomarker | Label mentions biomarker; actionability not inferred | Oncology | View source |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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