FGF23
Renal System · Renal Phosphate & Calcium Handling
How do bones help the kidneys regulate phosphate?
FGF23 encodes a hormone made by bone cells that acts on the kidneys. This signal helps balance phosphate, which is needed for bone strength and many cellular reactions.
- Common Gene Name
- fibroblast growth factor 23
- NCBI Gene ID
- 8074
- Chromosome
- 12
Clinical Evidence Status
Actionability report available
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (3 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| Hyperphosphatemic familial tumoral calcinosis | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2026-03 | |
| Kidney stones | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2026-03 | |
| Hypophosphatemic rickets, autosomal dominant | ClinGen clinical actionability | Scored report; not a validity grade | Pediatric | View source 2022-02-09 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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