GCK
Metabolic System · Insulin Signaling & Glucose Homeostasis
How do pancreatic cells sense changes in glucose?
GCK makes glucokinase, an enzyme that starts glucose processing in the liver and pancreatic beta cells. Its role in glucose sensing helps connect sugar availability with insulin regulation.
- Common Gene Name
- glucokinase
- NCBI Gene ID
- 2645
- Chromosome
- 7
Clinical Evidence Status
Established disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (6 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| monogenic diabetes | ClinGen gene-disease validity | Definitive | Semidominant | View source 2026-06-02 |
| hyperinsulinism due to glucokinase deficiency | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2026-06-17 |
| Congenital hyperinsulinism | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2020-07 | |
| Permanent neonatal diabetes mellitus | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2020-07 | |
| Gestational diabetes | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2020-07 | |
| Maturity-onset diabetes of the young | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2020-07 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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