GJB2

Sensory System · Auditory & Vestibular Mechanotransduction

How can communication between cells matter for hearing?

GJB2 makes connexin 26, which forms channels connecting neighboring cells. These channels support the movement of ions and small molecules needed for normal tissue function, including in the inner ear.

Common Gene Name
gap junction protein beta 2
NCBI Gene ID
2706
Chromosome
13

Clinical Evidence Status

Actionability report availableEstablished disease relationship

These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.

Answer Sources

Explore supporting evidence (9 records)
Condition or drugEvidenceGrade / statusContextSource
nonsyndromic genetic hearing lossClinGen gene-disease validityDefinitiveAutosomal recessiveView source
2024-09-24
hearing loss disorderClinGen gene-disease validityDefinitiveAutosomal dominantView source
2018-06-26
Nonsyndromic hearing lossMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2016-01
Vohwinkel syndromeMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2016-01
Palmoplantar keratoderma with deafnessMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2016-01
Bart-Pumphrey syndromeMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2016-01
Keratitis-ichthyosis-deafness syndromeMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2016-01
Hystrix-like ichthyosis with deafnessMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2016-01
Prelingual non-syndromic hearing loss and deafnessClinGen clinical actionabilityScored report; not a validity gradePediatricView source
2022-02-09

Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.

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