GLUL
Metabolic System · Amino Acid Catabolism & Nitrogen Clearance
How can cells turn ammonia into something useful?
GLUL encodes glutamine synthetase, which combines ammonia with glutamate to make glutamine. The reaction helps manage nitrogen while supplying an amino acid used in many other cellular processes.
- Common Gene Name
- glutamate-ammonia ligase
- NCBI Gene ID
- 2752
- Chromosome
- 1
Clinical Evidence Status
Disease evidence limited or conflicting
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (2 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| congenital brain dysgenesis due to glutamine synthetase deficiency | ClinGen gene-disease validity | Moderate | Autosomal recessive | View source 2024-12-13 |
| genetic developmental and epileptic encephalopathy | ClinGen gene-disease validity | Moderate | Autosomal dominant | View source 2025-01-07 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
← Back to Metabolic System