HADHA
Metabolic System · Fatty Acid Beta-Oxidation (Mitochondrial & Peroxisomal)
Why is HADHA called part of a trifunctional protein?
HADHA makes the alpha subunit of a mitochondrial enzyme complex that performs multiple steps in fat breakdown. These coordinated reactions help cells obtain energy from long-chain fatty acids.
- Common Gene Name
- hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
- NCBI Gene ID
- 3030
- Chromosome
- 2
Clinical Evidence Status
Actionability report availableEstablished disease relationshipTumor or drug-label biomarker context
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (4 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| long chain 3-hydroxyacyl-CoA dehydrogenase deficiency | ClinGen gene-disease validity | Definitive | Autosomal recessive | View source 2018-02-12 |
| Mitochondrial trifunctional protein deficiency | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2009-07 | |
| Disorders of the trifunctional protein complex | ClinGen clinical actionability | Scored report; not a validity grade | Pediatric | View source 2022-02-09 |
| Triheptanoin | FDA labeling biomarker | Label mentions biomarker; actionability not inferred | Inborn Errors of Metabolism | View source |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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