HDAC1
Universal Cellular Machinery · Chromatin Remodeling & Epigenetic Regulation
How can removing a chemical mark from histones change gene activity?
HDAC1 makes an enzyme that removes acetyl groups from histone proteins. Changing these marks influences DNA packaging and access to genes involved in cell growth and differentiation.
- Common Gene Name
- histone deacetylase 1
- NCBI Gene ID
- 3065
- Chromosome
- 1
Clinical Evidence Status
Disease evidence limited or conflicting
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (1 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| congenital heart disease | ClinGen gene-disease validity | Disputed | Autosomal dominant | View source 2024-01-08 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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