HFE
Hematologic System · Hematopoiesis, Erythropoiesis & Iron Homeostasis
Does an HFE result prove that I have too much iron?
HFE helps cells sense and regulate the body's iron supply. An associated variant does not directly measure iron overload, which requires interpretation with iron studies and the specific genetic result.
- Common Gene Name
- homeostatic iron regulator
- NCBI Gene ID
- 3077
- Chromosome
- 6
Clinical Evidence Status
Actionability report availableEstablished disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (5 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| hemochromatosis type 1 | ClinGen gene-disease validity | Definitive | Autosomal recessive | View source 2025-06-27 |
| Hereditary hemochromatosis | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2009-07 | |
| Porphyria | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2009-07 | |
| X-linked sideroblastic anemia | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2009-07 | |
| Hemochromatosis, Type 1 | ClinGen clinical actionability | Scored report; not a validity grade | Adult | View source 2023-06-28 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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