HNF1A
Universal Cellular Machinery · Transcription Factor Regulation
Why is HNF1A relevant to both the pancreas and liver?
HNF1A encodes a DNA-binding regulator especially important for gene activity in these organs. Their shared metabolic functions help explain the gene's relevance to some forms of inherited diabetes.
- Common Gene Name
- HNF1 homeobox A
- NCBI Gene ID
- 6927
- Chromosome
- 12
Clinical Evidence Status
Actionability report availableEstablished disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (6 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| monogenic diabetes | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2018-10-05 |
| Congenital hyperinsulinism | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2020-07 | |
| Type 1 diabetes | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2020-07 | |
| Maturity-onset diabetes of the young | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2020-07 | |
| Maturity Onset Diabetes of the Young Type I & Type III | ClinGen clinical actionability | Scored report; not a validity grade | Adult | View source 2026-01-13 |
| Maturity Onset Diabetes of the Young Type I & Type III | ClinGen clinical actionability | Scored report; not a validity grade | Pediatric | View source 2026-01-13 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
← Back to Universal Cellular Machinery