HNF1B
Universal Cellular Machinery · Transcription Factor Regulation
Can a gene regulator affect more than blood sugar?
HNF1B makes a regulator that controls developmental and functional programs in several organs. Its effects can therefore extend beyond glucose regulation, depending on the specific pathogenic finding.
- Common Gene Name
- HNF1 homeobox B
- NCBI Gene ID
- 6928
- Chromosome
- 17
Clinical Evidence Status
Actionability report availableEstablished disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (7 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| renal cysts and diabetes syndrome | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2021-01-19 |
| Prostate cancer | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2020-07 | |
| 17q12 deletion syndrome | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2020-07 | |
| Congenital anomalies of kidney and urinary tract | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2020-07 | |
| Maturity-onset diabetes of the young | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2020-07 | |
| Renal cysts and diabetes syndrome (RCAD) | ClinGen clinical actionability | Scored report; not a validity grade | Adult | View source 2024-08-07 |
| Renal cysts and diabetes syndrome (RCAD) | ClinGen clinical actionability | Scored report; not a validity grade | Pediatric | View source 2024-08-07 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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