HNF4A
Universal Cellular Machinery · Transcription Factor Regulation
How can HNF4A change the activity of many metabolic genes at once?
HNF4A encodes a transcription factor that binds selected DNA regions. By regulating multiple target genes, it coordinates broader tissue functions rather than carrying out a single metabolic reaction.
- Common Gene Name
- hepatocyte nuclear factor 4 alpha
- NCBI Gene ID
- 3172
- Chromosome
- 20
Clinical Evidence Status
Actionability report availableEstablished disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (5 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| monogenic diabetes | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2019-02-27 |
| Congenital hyperinsulinism | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2020-07 | |
| Maturity-onset diabetes of the young | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2020-07 | |
| Maturity Onset Diabetes of the Young Type I & Type III | ClinGen clinical actionability | Scored report; not a validity grade | Adult | View source 2026-01-13 |
| Maturity Onset Diabetes of the Young Type I & Type III | ClinGen clinical actionability | Scored report; not a validity grade | Pediatric | View source 2026-01-13 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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