HSPB8
Universal Cellular Machinery · Protein Folding & Chaperone Quality Control
Why might a stress-response protein matter in muscle and nerve health?
HSPB8 encodes a small heat-shock protein involved in protecting cells under stress. Long-lived cells depend on protein maintenance, helping explain interest in its role in neuromuscular disease.
- Common Gene Name
- heat shock protein family B (small) member 8
- NCBI Gene ID
- 26353
- Chromosome
- 12
Clinical Evidence Status
Established disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (4 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| neuronopathy, distal hereditary motor, autosomal dominant | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2021-03-22 |
| Charcot-Marie-Tooth disease | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2025-03 | |
| Distal hereditary motor neuropathy, type II | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2025-03 | |
| Myofibrillar myopathy | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2025-03 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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