IDH1

Universal Cellular Machinery · Core Enzymatic Catalysis & Cofactor Chemistry

How is IDH1's normal metabolic role different from a tumor mutation?

IDH1 makes an enzyme that normally converts isocitrate into another metabolic compound. Particular tumor-associated variants can change enzyme behavior, so their meaning cannot be assigned to every IDH1 finding.

Common Gene Name: isocitrate dehydrogenase (NADP(+)) 1
NCBI Gene ID: 3417
Chromosome: 2

Clinical Evidence Status

Tumor or drug-label biomarker context

These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.

Answer Sources

Explore supporting evidence (9 records)

Condition or drug	Evidence	Grade / status	Context	Source
Maffucci syndrome	MedlinePlus related condition	Association type varies; no grade assigned here		View source 2016-02
Primary myelofibrosis	MedlinePlus related condition	Association type varies; no grade assigned here		View source 2016-02
Cytogenetically normal acute myeloid leukemia	MedlinePlus related condition	Association type varies; no grade assigned here		View source 2016-02
Ollier disease	MedlinePlus related condition	Association type varies; no grade assigned here		View source 2016-02
Cholangiocarcinoma	MedlinePlus related condition	Association type varies; no grade assigned here		View source 2016-02
Ivosidenib	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Oncology	View source
Olutasidenib	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Oncology	View source
Venetoclax (4)	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Oncology	View source
Vorasidenib (1)	FDA labeling biomarker	Label mentions biomarker; actionability not inferred	Oncology	View source

Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.

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