IFIH1
Immune System · Interferon Cascades & Antiviral Defense
How can a cell recognize RNA from a virus?
IFIH1 makes MDA5, a sensor that detects certain double-stranded RNA structures. Recognition can trigger innate immune responses before the body develops a more targeted defense.
- Common Gene Name
- interferon induced with helicase C domain 1
- NCBI Gene ID
- 64135
- Chromosome
- 2
Clinical Evidence Status
Established disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (3 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| IFIH1-related type 1 interferonopathy | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2024-08-23 |
| Aicardi-Goutières syndrome | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2024-09 | |
| MDA5 deficiency | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2024-09 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
← Back to Immune System